All-Star point guard Kyrie Irving (knee) and center Tristan Thompson (thumb) also could be held out. Cleveland listed its probable starters as Deron Williams, Iman Shumpert, J.R. Smith, Richard Jefferson and Channing Frye.
Irving will not play in Monday's game against the Heat due to rest purposes, Joe Vardon of Cleveland.com reports. The Cavs have the fewest wins a LeBron-led team has had since the 2007-08 season.
A loss Sunday followed when Cleveland, playing against Atlanta's traditional lineup, failed to protect a 26-point fourth-quarter lead and went on to lose 126-125 in overtime.
For the Heat, the victory means they will be fighting with the Indiana Pacers and Chicago Bulls for the last two playoff spots in the East when the regular season concludes tomorrow.
Even with a loss to the Raptors, the Cavaliers can not drop lower than the No. 2 seed, and would likely play the Indiana Pacers in the first round of the playoffs.
Chicago (40-41) hosts Brooklyn (20-61) and IN (41-40) hosts Atlanta (42-38). Chicago hosts Orlando and Brooklyn.
The Heat now lead the season series against the Cavaliers 2-1 and have won a franchise-record 12 straight games against them at home.
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James did not play in Monday's loss at Miami and general manager David Griffin confirmed Tuesday the three-time National Basketball Association champion will also miss Wednesday's game against Toronto.
"I think it was just keeping everybody locked in and starting everything on the defensive end", Richardson said immediately after the victory. I had visions of another shot from my first year of one of our former players on another team.
The team apparently made a decision to give the star players rest before the playoffs over continuing the fight for the No. 1 seed in the Eastern Conference. Their longest win streak of the season was a measly six, when they started 6-0, while they had five separate three-game losing streaks, which suggests that the whole, "they might be vulnerable, but how are they going to lose four times in seven games?" argument might be misguided.
LeBron James sat out Monday night's game against the Heat with an announced calf injury.
Despite just a 5-5 record in their past 10 games, Lue expressed confidence in how his team would perform when the playoffs open this weekend.
"This school is so important to me because our vision is to create a place for the kids in Akron who need it most - those that could fall through the cracks if we don't do something", James said. "I base it on we're still the champs. But we fought back". "We're the No. 1 seed right now, and it's our job to take care of business tomorrow". How many of you are exhausted today and still doing your job? "I feel really good about our team".