Cholesterol drug drops heart risks, but ignites new price debate

In FOURIER, 27,500 patients were enrolled into the trial and randomly allocated to treatment with either an optimised regimen of statin drugs or statins plus Repatha.

Researchers from Imperial College London in the United Kingdom and colleagues, who conducted the trial, said the twice-a-year treatment could be safely given with or without statins, depending on individual patient needs.

While doctors said they were relieved that Repatha is safe, doctors such as David Rind said they had hoped the study would show that the injectable medication reduces heart attacks and other serious complications by 30 percent or more, given its success in early studies. The sanction was done without any evidence it showed great results in reducing cholesterol.

In all, Krumholz believes that Amgen did a "solid" job with its study and getting Repatha to market, despite the new questions posed.

It shows that for every 74 people given the drug for two years alongside statins, one heart attack, stroke or death would be prevented.

However, Prof Sever said: "They will probably not [replace statins], there are an bad lot of people with really quite high cholesterol out there and we'll probably need more than one drug to get their levels down".

A powerful cholesterol drug cuts the risk of heart attacks by a quarter, a landmark trial has found. Those on the highest tier might include specialty medicines that could cost the patient hundreds of dollars even with coverage.

And if guidelines are changed on the back of the new results, thousands more could benefit.

Amgen Inc. presented detailed data for the FOURIER cardiovascular outcomes trial of its Repatha (evolocumab) at the American College of Cardiology (ACC) annual meeting today. About 10% of patients taking the drug had a heart attack or stroke, or died of heart disease during the trial. Half of these patients were given optimal quantity of statins along with Repatha, and the other half were given a placebo.

Fed's Caution Propels Euro to One-Month High
CURRENCIES: The euro from dipped to $1.0746 from $1.0749 late Thursday, and the British pound fell to $1.2367 from $1.2358. MSCI's emerging equity index jumped almost 2 percent - the biggest daily gain since last July - after the U.S.

Those who took both were less likely to suffer a heart attack or stroke than if they took statins alone. In fact, the magnitude of the risk reduction in the hard MACE composite endpoint grew over time, from 16 percent in the first year to 25 percent beyond the first year.

On Friday, for the first time, we saw the full data from the FOURIER clinical trial of Amgen's cholesterol-lowering antibody, evolocumab (Repatha™).

The benefit of Repatha was seen on those tested within six months. We also asked patients and their physicians to provide their assessments and found no differences between evolocumab and placebo.

The drugs work by blocking a protein that affects the liver's ability to remove cholesterol from the blood.

Heart disease and stroke are the number one killers worldwide, taking 15 million lives in 2015, according to the World Health Organization.

Nearly 14,000 patients were recruited to the treatment arm of the study, receiving the drug over a 48-week period. But in the Mizuho Securities conference call, participants agreed that a reasonable estimate of the direct hospital cost of treating a stroke is around $20,000 to $40,000, while the total lifetime costs are about $100,000 for an elderly patient, and up to $500,000 for a young patient.

Cardiologists have always been taught that CV patients have three risk factors that can be handled with treatment: high blood pressure, smoking and high LDL cholesterol, Levy said.

Professor Sir Nilesh Samani, medical director at the British Heart Foundation, said the trial was a 'significant advance, ' adding: 'While statins have had a significant impact in reducing the risk of heart disease for millions of people, they are not tolerated by everyone and only reduce cholesterol by a certain amount'.

The EBBINGHAUS study, a double-blind, placebo-controlled randomized non-inferiority trial, included a cohort of 1,204 patients.

Related Articles

  • Russell Westbrook misses fifth straight triple-double, but Thunder get a win

    Russell Westbrook misses fifth straight triple-double, but Thunder get a win

    Quotable: "We've played (in Oklahoma City) plenty of times ". Westbrook later promised, "I'm gonna get his a- back". We just had to find ways to get guys going.

    Stephen Colbert lampoons Rachel Maddow's long-winded Trump tax reveal

    That does not support arguments from left-wing voters during the campaign that Trump doesn't actually pay federal taxes. The vice chairman of that bank until recently was our new secretary of commerce, long time Trump friend Wilbur Ross'.

    PALMER INVITATIONAL: Hoffman's long birdie gives him share of Palmer lead

    The King will not be waiting at the top of the hill to greet the victor with his customary firm handshake and megawatt smile. Two Englishman, Matthew Fitzpatrick and Tyrrell Hatton, and Australian Marc Leishman are tied for third two strokes behind.
  • Drake Finally Got His 'Life' Together

    Drake Finally Got His 'Life' Together

    Discussing the idea for More Life late previous year , he said, "I'm off, like, mixtapes, I want to do a playlist". He told his fans that he was six or seven songs into his next project and added he was in the studio every night.
    Le Pen ups promises to French Polynesia

    Le Pen ups promises to French Polynesia

    She also thanked Brexit-voters for "showing us the way out from this huge prison which is the European Union for the people". In a promotional tweet ahead of the broadcast at 7pm on Wednesday night, LBC called the interview " unmissable ".
    Texas House Approves Texting While Driving Ban… Again

    Texas House Approves Texting While Driving Ban… Again

    Donna Campbell, R-New Braunfels, who said said "dismemberment" abortion constitutes "cruel and unusual punishment". Jones also said if the charter bill passes and is signed into law, it should be challenged as unconstitutional.
  • Jurgen Klopp confident he is the right manager for Liverpool

    Jurgen Klopp confident he is the right manager for Liverpool

    City fought back from 2-0 down and were momentarily in control after midfielder Leroy Sane's 71st-minute goal. You have to be a little bit more realistic", Guardiola told reporters today.
    Michael Flynn received almost  $34000 to attend event with Putin

    Michael Flynn received almost $34000 to attend event with Putin

    In his letter, Cummings requested further investigation into Flynn's payments, which he had not previously disclosed. An additional $11,250 was paid to Leading Authorities, Flynn's speaking agents.
    Nicola Sturgeon claims mandate for Scottish independence vote

    Nicola Sturgeon claims mandate for Scottish independence vote

    Last June, the United Kingdom voted to leave the European Union , but Scots were firmly opposed, with 62 percent voting to remain. Sturgeon also said she wanted a vote to be held between the autumn of 2018 and the spring of the following year.
  • Israel to 'continue' targeting Hezbollah-bound arms in Syria

    Facebook pages associated with Bashar al-Assad's government meanwhile claimed a citizen named Yasser Esayed was killed. Israeli warplanes had attacked several targets in Syria, the IDF said, prompting the Syrian attack.
    Yogi Adityanath appointed as new cm of UP

    Yogi Adityanath appointed as new cm of UP

    The Prime Minister had already left for Dehradun to witness the swearing of Uttarakhand chief minister Trivendra Singh Rawat. The yogi then launched the Hindu Yuva Vahini , which helped him establish his dominance over the region.
    Mass Effect 1 Had Better Animations Than Andromeda?

    Mass Effect 1 Had Better Animations Than Andromeda?

    Fans thought that BioWare has finally fixed the problem when they released one of the game trailers containing a love scene. Note, however, that this latest reservation for Mass Effect Andromeda does not allude to the rest of the game's aesthetics.